Yale scientists have uncovered how energy patterns within cells drive crucial processes like division, wound healing, and immune responses.

The discovery focuses on the cell’s cortex, which consists of the membrane and internal structures. Scientists observed that before cells divide, they produce two distinct types of protein wave patterns—one rhythmic, pulsing like a heartbeat, and another chaotic, yet organized in spiral formations. This breakthrough not only advances our understanding of cellular behavior but also opens potential pathways for developing treatments for diseases like cancer​.

By analyzing these wave patterns, the research team, led by Michael Murrell at Yale’s Systems Biology Institute, revealed that cells operate within an optimal energy state. This balance between the two wave types maximizes the energy available for cellular functions, such as growth and recovery. Understanding these dynamics can lead to more efficient disease treatment strategies​.

Using thermodynamic principles, postdoctoral fellow Sheng Chen measured how mechanical and chemical energy waves interact. The researchers found that far from being random, the energy waves follow precise rules of dissipation, indicating an organized and energy-efficient system. This discovery has far-reaching implications for biological engineering and medical research​.

This research lays the groundwork for future applications of machine learning and mathematical models to quantify how energy patterns relate to diseases, particularly cancer. The Yale team is collaborating with other universities to deepen this exploration​.

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