A biological computer built from living human neurons is now interacting with Doom.

Developed by Australian biotechnology company Cortical Labs, the CL1 combines roughly 200,000 lab-grown human neurons with silicon electronics, allowing software to send information to the cells and translate their electrical responses back into digital commands.

There is no person holding the controls. Instead, the neurons receive encoded information about the game, respond through changing patterns of electrical activity and gradually adapt through feedback.

The result is still primitive compared with a human gamer or modern AI agent, but the experiment provides a striking demonstration of biological computing—or “wetware”—operating inside a real-time digital environment.

What makes CL1 important is not Doom itself. The game is effectively a benchmark demonstrating that living neural networks can be connected to conventional computing infrastructure and used as adaptive information-processing systems.

If the technology scales, biological computing could eventually influence neuroscience, pharmaceutical research, robotics and new forms of low-power computing that operate very differently from GPUs and CPUs.

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